Antibody Discovery for Enzyme Conjugates

Question: Why is specialized antibody discovery essential for the development of Antibody-Directed Enzyme Prodrug Therapy (ADEPT)?

Answer: ADEPT relies on the precise delivery of an enzyme to the tumor site, which then converts a non-toxic prodrug into a potent cytotoxic agent. A tailored antibody discovery service for enzyme conjugates ensures that the resulting antibodies possess high affinity and high internalization rates (if required), or optimal retention on the cell surface to facilitate efficient enzymatic turnover within the tumor microenvironment.